Monday, April 29, 2013

As we predicted, pensions eating up Prop. 30 education funds ...

Prop. 30 not enough, Dec. 3, 2012April 30, 2013

By John Seiler

As Bill Clinton might put it, it?s in the math.

In the lead up to the November 6 election last fall, CalWatchDog.com ran several articles on Proposition 30 and pensions. We warned that?the $7 billion tax increase would go not to schools, as advertised by Gov. Jerry Brown and others in TV ads, but to teacher pensions and other spending. I?ll quote some below.

The news now is that this is exactly what is happening. David Crane, a Democrat who was a budget adviser to Republican Gov. Arnold Schwarzenegger, has the facts in a Bloomberg article:

?Most Californians would be surprised to learn that 100 percent of education?s share of the tax increase proposed by Governor?Jerry Brown?will go to pensions instead of classrooms. But that would be no surprise to longtime observers of the?California?State Teachers? Retirement System, which administers teacher pensions.

?Here?s why: After retirement, teachers are unconditionally guaranteed lifetime pensions by their school districts. Everything works out fine if?Calstrs, as the retirement system is known, earns the investment returns it forecasts and from which upfront contributions are derived.

?But if they fall short, school districts must make up the difference. Because of compounding, the failure to earn forecasted earnings translates into huge deficiencies down the road.

?Unfortunately, ?down the road? is where school districts are now.

He noted something Katy Grimes?reported here in March on a Legislative Analyst Report, which found that the California State Teachers Retirement System needs $4.5 billion a year in new funding to keep afloat. Prop. 30 now is pected to bring in $7 billion in new revenues. Crane noted that, because of Proposition 98, about 40 percent of any new revenue must go to schools. He wrote, ?[T]hat means?almost $3 billion a year for the schools to use for pensions, or two-thirds of the Calstrs $4.5 billion request. A good start to meeting pension costs, but none of the tax increase will benefit students.?

So the pensions will eat up all the $3 billion from Prop. 30 going to ?schools? ? plus another $1.5 billion from other general-fund dollars.

How did CalSTRS get in the mess? Crane explained:

?In short, it failed to take?Warren Buffett?s advice. In 1999, Buffett said that long-term investors, such as pension funds, should assume investment returns of roughly 6 percent a year, not far from the actual return earned since then. Had Calstrs used his figure for its projections of the fund?s growth, it would have required larger contributions from school districts, employees and the state, and Calstrs would be healthier now.

?But the retirement fund?s board ? made up of the state?s chief financial officials and others ? chose to forecast much higher investment returns that, as Buffett later pointed out, implicitly predicted the stock market portion of the Calstrs portfolio to perform 10 times better than stocks did in the 20th century.?

CalWatchDog.com predicted the Prop. 30 legerdemain

All of this was known to readers of CalWatchDog.com before the election because we reported on it.

I wrote on Sept. 12?in an article?titled, ?California Budget Project analysis of Prop. 30 slights slam to business, jobs?:

?Being pushed by Gov. Jerry Brown and the state?s powerful government-worker unions, Prop. 30 would increase sales and income taxes taxes by from $6 billion to $8.5 billion a year. Supposedly the money would preclude cuts in K-12 and college education. But there?s no guarantee the higher taxes wouldn?t go toward the state?s burgeoning pension costs for retired government workers. All government money is fungible.?

I ?also wrote on Oct. 27?in an article titled, ?Yes, Prop. 30 would fund pensions?:

?If Proposition 30 passes, the $6 billion it would soak from taxpayers would just go straight to public-employee pensions?.

?In sum, the $6 billion from Prop. 30 would go to pay $6.4 billion in state pension payments.

?Everything else is a deception.?

On Oct. 31, Steven Greenhut wrote?in an article titled, ?Pay soars in the public sector?:

?Californians are stuck watching those dreadful union-financed campaign TV ads supporting?Proposition 30, which would push our highest income-tax rates to the stratosphere and boost sales taxes. The main rationale for high taxes, we?re told, is that California is slashing public school funding and laying off teachers?.

?What will happen if California voters approve Prop. 30? Check out the many bills that moved through the Legislature this session, as legislators crafted new proposed programs and benefit increases for their public-employee constituents.?

On Nov. 2, Wayne Lusvardi wrote in an article titled, ?Prop. 30 would make budget roller coaster more scary?:

?Declaring that K-12 public school budgets would have to be cut [unless Prop. 30 passed] is the way the state socially constructs and manages a budget crisis.? It is never portrayed that it is the Medi-Cal or public pension funds that are running a deficit. Public school children are used as poster children every year for any revenue shortfalls in health and welfare programs, pensions, or bond debts?.

?In the above table [in the Lusvardi article], it appears that the hole in the state budget is in the Bond Fund. This would include the liability for public pensions. Retirement benefit costs have increased from $1.4 billion in 1999 to?$6.5 billion?this fiscal year.?

For reference, here?s one of the misleading TV ads the Prop. 30 campaign ran:

Tags: David Crane, Jerry Brown, John Seiler, Prop. 30, tax increase

Source: http://www.calwatchdog.com/2013/04/29/pensions/

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Google invades Siri's turf with iPhone, iPad app

This undated image made available by Google shows "Google Now." Google is trying to upstage Siri, the sometimes droll assistant that answers questions and helps people manage their lives on Apple's iPhone and iPad. The duel begins Monday, April 29, 2013, with the release of a free iPhone and iPad app that features Google Now, a technology that performs many of the same functions as Siri. (AP Photo/Google)

This undated image made available by Google shows "Google Now." Google is trying to upstage Siri, the sometimes droll assistant that answers questions and helps people manage their lives on Apple's iPhone and iPad. The duel begins Monday, April 29, 2013, with the release of a free iPhone and iPad app that features Google Now, a technology that performs many of the same functions as Siri. (AP Photo/Google)

(AP) ? Siri may be feeling a little job insecurity. The sometimes droll assistant that answers questions and helps people manage their lives on Apple's iPhone and iPad is facing competition from an up-and-coming rival made by Google.

The duel began Monday with the release of a free iPhone and iPad app that features Google Now, a technology that performs many of the same functions as Siri.

It's the first time that Google Now has been available on smartphones and tablet computers that aren't running on the latest version of Google's Android software. The technology, which debuted nine months ago, is being included in an upgrade to Google's search application for iOS, the Apple Inc. software that powers the iPhone, iPad and iPod Touch. It's up to each user to decide whether to activate Google Now within the redesigned Google Search app, which is available through Apple's app store.

Siri tried to dismiss the competitive threat. When asked for an opinion about Google Now, Siri responded: "If it's all the same to you, I'd rather Google later."

Mike Allton, a St. Charles, Mo., resident who has owned an iPhone for four years, could hardly wait to check out Google Now, even if Siri might interpret it as a betrayal.

Siri "is looking a little green with envy," Allton, 36, said with a laugh after he installed Google's new app. "I love Apple products, but I like to see the competition because it probably will lead to even more improvements. I believe this technology is going to be even more deeply ingrained in our lives a few years from now."

Other iPhone users ? even those who have grown fond of Siri ? welcomed Google Now's arrival to iOS in mostly enthusiastic and sometimes amusing remarks posted on Twitter and Google Plus. One person joked that Google Now is so helpful that the technology prompted him to wash his hands after using the bathroom. The biggest gripe was about the possibility of Google Now's location-tracking features draining a device's battery more quickly.

Google Now's invasion of Siri's turf marks Google Inc.'s latest attempt to lure iPhone and iPad users away from a service that Apple built into its own devices.

Google quickly won over millions of iPhone users in December when it released a mapping application to replace the navigation system that Apple dumped when it redesigned iOS last fall. Apple's maps application proved to be inferior to Google's ousted service. The app's bugs and glitches made Apple the butt of jokes and fueled demand for Google to develop a new option.

Apple has been losing to Google on other fronts in a rapidly growing mobile computing market, an arena that was revolutionized with the iPhone's release in 2007. Smartphones and tablet computers running Google's free Android software have been steadily expanding their market share in recent years, partly because they tend to be less expensive than the iPhone and iPad. In 2012, Android devices held about 69 percent of the smartphone market while iOS had about 19 percent, according to the research firm IDC.

Android's success has been particularly galling for Apple because its late CEO, Steve Jobs, believed Google stole many of its ideas for the software from the iPhone. That led to a series of court battles over allegations of patent infringement, including a high-profile trial last year that culminated in Apple winning hundreds of millions in damages from Samsung Electronics, the top seller of Android phones. That dispute is still embroiled in appeals.

The rise of Android also is squeezing Apple's profit margins and has contributed to a nearly 40 percent drop in the company's stock price since it peaked at $705.07 last September around the time that the iPhone 5 came out.

Android's popularity is good news for Google because the company's services are built into most versions of the operating system. That brings more traffic to Google services, creating more opportunities for the company to sell ads ? the main source of Google's revenue.

Siri is billed by Apple as an "intelligent feature." Since the technology's release in October 2011, Apple has made it a centerpiece of some marketing campaigns that depict Siri and its automated female voice as an endearing and occasionally even pithy companion.

Google believes its Siri counterpart is smarter because Google Now is designed to learn about a user's preferences and then provide helpful information before it's even asked to do so. The technology draws upon information that Google gleans from search requests other interactions with the company's other services. Knowing a person's location also helps Google Now serve up helpful information without being asked.

"This concept of predicting your needs and showing you them at the right time is unique to Google Now," said Baris Gultekin, Google Now's director of product management. "We want computers to do the hard work so our users can focus on what matters to them so they can get on with their lives."

If the technology is working right, Google Now is supposed to do things like automatically tell people what the local weather is like when they wake up to help decide what to wear and provide a report on traffic conditions for the commute to work. During the day, Google Now might provide an update on the score of a user's favorite sports team or a stock quote of a company in a user's investment portfolio. On a Friday evening, Google Now might offer suggestions for movies to see or other weekend events tailored to a user's interests. For international travelers, Google Now might provide currency conversion rates, language translations of common phrases and the time back home.

Most of this automatic information is provided in summaries that Google calls "cards." Like Siri, Google Now also is equipped with voice technology that allows it to respond to questions and interact with users, though it hasn't shown the wit that delights some of Siri's users.

The Google Now app for iOS isn't as comprehensive as the Android app, which only works on devices running on the latest version of Android ? known as "Jelly Bean." Some of the Android features missing from Google Now's iOS app include cards for showing airline boarding passes and movie tickets bought though online vendor Fandango. Both of those options are available on the iOS through Apple's built-in Passbook feature that's designed to be a digital wallet.

Google Now's expansion on to the iOS underscores Google's ambitions for the service. The company, which is based in Mountain View, Calif., views it as a pivotal tool in its effort to peer deeper into its users' brains. In doing so, Google believes it will be able to provide more useful services and also show more relevant ads. For Google Now to become more intuitive, it needs to widen its availability.

"The more you use Google Now, we will have a better chance of understanding what your needs are and providing you with the right information," Gultekin said. "It's a virtuous cycle."

Shawn Jacob, a student at the University of North Texas, activated Google Now on his iPhone Monday and was startled by how much the service already knew about him when he logged in for the first time. "I was blown away," Jacob, 21, said. "It made me wonder if I really want Google to know this much about me. It's like Google wants to take over the world."

Gultekin declined to discuss whether there are plans to make Google Now apps for mobile devices running on Microsoft's Windows system. He also refused to comment on speculation circulating in technology blogs that a Web version of Google Now will be offered as a replacement for iGoogle, a tool that allows people to encircle the Google search engine with a variety of services suited to their tastes. IGoogle is scheduled to close in November.

___

Online:

http://www.google.com/landing/now/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-29-Google-Apple-Dueling%20Assistants/id-922de12ef38041d59010ae22b654a7d3

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Chrysler investing $20M in Toledo plant to support 9-speed auto ...

Chrysler Group Plans to Invest Nearly $20 Million in Toledo Machining Plant

- Investment to increase capacity for production of torque converters for new generation, fuel-efficient nine-speed transmission
- Company's total investment in U.S. facilities over $5.2 billion since June 2009

April 26, 2013 , Auburn Hills, Mich. - Chrysler Group LLC announced today that it will invest $19.6 million in its Toledo Machining Plant in Perrysburg, Ohio, to increase capacity of the torque converter it's machining for the nine-speed transmission. With this announcement, the Company's total investments in its U.S. operations since June 2009 increase to over $5.2 billion.

The new torque converters will be paired with the next generation, fuel efficient nine-speed front-wheel drive transmission being assembled at Chrysler Group's Indiana (Kokomo, Ind.) Transmission Plant I. The new transmission will debut in the 2014 Jeep? Cherokee.

"The new nine-speed transmission is a critical part of our strategy to meet fuel economy requirements over the next several years and Toledo Machining will play an integral role in bringing this transmission to market," said Scott Garberding, Senior Vice President, Manufacturing, Chrysler Group LLC. "Securing this additional investment is a testament to the dedication and commitment of the plant's workforce and helps secure its future long-term."

The investment will fund the installation of new equipment and tooling for additional machining and assembly capacity. Installation is expected to begin in the third quarter of 2014 and will be completed by the end of 2014.

In August 2011, a $72 million investment in Toledo Machining was announced to modernize the plant to produce the eight- and nine-speed torque converters on two new production lines and a new steering column for the Dodge Dart and Jeep Cherokee. These installations will be complete in the third quarter this year.

"We're very pleased that Chrysler is once again investing in the Toledo Machining Plant and the skilled workforce there," said General Holiefield, Vice President and Director, UAW Chrysler Department. "This will help preserve and enhance jobs in the area and give a greater measure of security to our members and their families well into the future."

In February, the Company announced that it was investing $374 million in several of its Kokomo, Ind., facilities, including establishing a new manufacturing site in Tipton, Ind., to increase production capacity of the nine-speed transmission.

Toledo Machining currently produces torque converters for Kokomo Transmission (Ind.), Indiana Transmission I and II (Kokomo, Ind.), Sterling Heights Assembly (Mich.), and Toluca (Mex.).

The plant also produces steering columns for the following assembly plants: Warren Truck (Mich.), Belvidere (Ill.), Sterling Heights (Mich.), Toledo Assembly Complex (Ohio); Windsor (Ont.), Toluca (Mex.), Saltillo (Mex.), Arab American Vehicles (Egypt) and Carabobo (Venezuela).

Source: http://www.autoblog.com/2013/04/28/chrysler-investing-20m-in-toledo-plant-to-support-9-speed-auto/

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Muslim group says spray-painting of Oklahoma mosque may be Boston backlash

By Erin McClam, Staff Writer, NBC News

Police said Saturday they were investigating what a Muslim advocacy group described as an act of vandalism against an Oklahoma City mosque that may have been part of a backlash after the Boston Marathon bombings.

Words were spray-painted on the mosque before dawn Saturday, said Lt. Arthur Gregory, a spokesman for Oklahoma City police. He said he did not know the nature of the words.

The Council on American-Islamic Relations said in a statement that the words were obscenities. It wants the matter investigated as a hate crime and wants state and federal law enforcement to determine whether the vandalism was a reaction to the bombings.

The surviving suspect in the marathon attack, Dzhokhar Tsarnaev, has told investigators that he and his brother set off the bombs to defend Islam after the American wars in Afghanistan and Iraq.

The council said that the same mosque was targeted by paintballs last year, and said there have been other acts of violence against American Muslims since the marathon bombings.

In Malden, Mass., two days after the blasts, a Muslim woman wearing traditional Islamic hijab told police and The Boston Globe that she was punched on the street by a man who cursed at her and shouted, ?You are terrorists.?

This story was originally published on

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Google Now available on iOS devices starting today

Google Now available on iOS devices starting today

When it comes to major news, we didn't expect to hear much from Google in the run-up to I/O, but clearly, the company just couldn't wait that long. Google Now, a service that Android users have enjoyed for a year, just became available on iOS devices in the form of an update to the Google Search app, confirming those leaked videos we saw a few weeks ago. It won't have integration with notifications or alerts at launch -- it may come in a future update, but the company wasn't willing to divulge its future plans -- so you'll need to enter the app and swipe up to refresh your list of cards. The iOS version won't have every type of card that you'll find on Android, either: boarding passes, activity summary, events, concerts, Fandango and Zillow aren't included this go-round. Improvements and additional features will likely trickle in over time, but it's certainly better than nothing for iOS fans who've looked at Jelly Bean users with a slightly jealous eye. We've included Google's blog post in its entirety below, and you can jump to More Coverage to download the app.

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Source: The Official Google Blog, iTunes

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/IfRW3CkQ4nQ/

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Friday, April 26, 2013

Engadget Mobile Podcast 178 - 04.26.13

Engadget Mobile Podcast 178 - 04.26.13

New phones usually enjoy a big comfortable seat in the limelight when they land. This week, however, there's a lot less elbow room thanks to the recent deluge. But, despite much more muscular competition, that cheeky Nokia 210, still manages to get in there first. Enjoy the show.

Hosts: Myriam Joire (tnkgrl), Brad Molen, Joseph Volpe

Producer: James Trew

Music: Tycho - Coastal Brake (Ghostly International)

Hear the podcast

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Source: http://www.engadget.com/2013/04/26/engadget-mobile-podcast-178-04-26-13/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Israeli military shoots down drone

An Israeli military naval ship and an Israeli air force helicopter operate off the coast of Haifa , northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. (AP Photo/Ariel Schalit)

An Israeli military naval ship and an Israeli air force helicopter operate off the coast of Haifa , northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. (AP Photo/Ariel Schalit)

An Israeli military naval ship and an Israeli air force helicopter operate next to a cruise ship off the coast of Haifa, northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. (AP Photo/Ariel Schalit)

An Israeli military naval ship and an Israeli air force helicopter operate off the coast of Haifa, northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. (AP Photo/Ariel Schalit)

Israel's Prime Minister Benjamin Netanyahu, center, attends the holiday of Nabi Shoaib, the Prophet Jethro, during a cultural event with members of the country's Druse minority in the Druse village of Julis, northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. Netanyahu, who was in northern Israel at the time of the incident, said he viewed the infiltration attempt with "utmost gravity." (AP Photo/Ariel Schalit)

Israel's Prime Minister Benjamin Netanyahu, center, is welcomed by Druse leaders for the holiday of Nabi Shoaib, the Prophet Jethro, during a cultural event with members of the country's Druse minority in the Druse village of Julis, northern Israel, Thursday, April 25, 2013. Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon. The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006. Prime Minister Benjamin Netanyahu, who was in northern Israel at the time of the incident, said he viewed the infiltration attempt with "utmost gravity." (AP Photo/Ariel Schalit)

(AP) ? Israel shot down a drone Thursday as it approached the country's northern coast, the military said. Suspicion immediately fell on the Hezbollah militant group in Lebanon.

The incident was likely to raise already heightened tensions between Israel and Hezbollah, a bitter enemy that battled Israel to a stalemate during a monthlong war in 2006.

Prime Minister Benjamin Netanyahu, who said he was in a helicopter in northern Israel at the time of the incident, said he viewed the infiltration attempt with "utmost gravity."

Officials said Netanyahu was informed of the unfolding incident as he was flying north for a cultural event with members of the country's Druse minority. They said his helicopter briefly landed while the drone was intercepted before Netanyahu continued on his way.

"On my way here in the helicopter, I was told that there is an infiltration attempt of a drone inside the skies of Israel," he said in the northern Arab-Israeli town of Daliyat al-Karmel. "We will continue to do everything necessary to safeguard the security of Israel's citizens."

Lebanon's state-run National News Agency reported that Israeli warplanes flew over the Christian town of Jezzine and the highlands of the Iqlim al-Tuffah province, a Hezbollah stronghold in southern Lebanon, Thursday morning.

The Lebanese army also reported Israeli jets violated Lebanese air space on Tuesday and Wednesday. Israel has stepped up its flights over Lebanon amid fears that Hezbollah is taking advantage of the chaos caused by the Syrian civil war.

Lt. Col. Peter Lerner, a military spokesman, said the unmanned aircraft was detected as it was flying over Lebanon and tracked as it approached Israeli airspace.

Lerner said the military waited for the aircraft to enter Israeli airspace, confirmed it was "enemy," and then an F-16 warplane shot it down.

The drone was flying at an altitude of about 6,000 feet (1,800 meters) and was downed roughly five miles (eight kilometers) off the Israeli coast near the northern city of Haifa. Lerner said Israeli naval forces were searching for the remains of the aircraft.

He declined to say who sent the drone.

Other military officials, speaking on condition of anonymity because they were not permitted to talk to the media, said they believed it was an Iranian-manufactured aircraft sent by Hezbollah. The Lebanese group sent a drone into Israeli airspace last October that Israel also shot down.

Netanyahu repeatedly has warned that Hezbollah might try to take advantage of the instability in neighboring Syria, a key Hezbollah ally, to obtain what he calls game-changing weapons.

Israel has all but confirmed that it carried out an airstrike in Syria early this year that destroyed a shipment of sophisticated anti-aircraft missiles bound for Hezbollah.

A senior Lebanese security official, who also spoke on condition of anonymity in line with regulations, said Lebanon had no information on Thursday's incident.

Hezbollah spokesman Ibrahim Moussawi also said he had no information, adding the group would put out a statement if it had something to say on the issue.

When Israeli military shot down a Hezbollah drone on Oct. 6, it took days for Hezbollah leader Sheik Hassan Nasrallah to confirm it in a speech. He warned at the time that it would not be the last such operation by the group. He said the sophisticated aircraft was made in Iran and assembled by Hezbollah.

___

Associated Press writers Zeina Karam in Beirut and Diaa Hadid in Jerusalem contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-25-Israel-Hezbollah/id-b438d8b4d0374eeeb98b70c4f4cfab0c

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Apple Patents Built-In iPhone Remote Unlocker, Engine Starter And Parking Locator For Cars

Screen Shot 2013-04-25 at 7.33.44 AMThe USPTO published a number of Apple patent applications Tuesday, including two related to automobiles (via AppleInsider). The car patents both describe systems that can be built into future iPhones, replacing most of the functionality of your standard key fob with the smartphone, and providing a way to help drivers navigate the often maze-like interiors of parking garages to find their ride.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/j2yXUuXSQog/

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Viber exploit lets attackers bypass Android lock screens, for now (video)

Viber exploit lets users bypass Android lock screens, a fix is on the way video

If you're an Android user who prefers Viber for VoIP and messaging, you may not want to leave your phone unattended in the near future. Bkav Internet Security has discovered an exploit that will bypass the lock screen on Android phones new and old (including the Nexus 4) as long as pop-up notifications are active. While the exact actions vary from phone to phone, all that's really needed is an incoming message or two, a handful of taps and the back button to reach the home screen. App users can disable the pop-ups as a short-term workaround, although they thankfully won't have to do that for long when Viber promises that a patch is on the way. There's only a small chance that a malicious attacker will both get their mitts on your phone and know that you've got Viber installed, but we'd advise against using statistical probability as a security measure.

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Via: Ars Technica

Source: Bkav

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qVgLeHVcRwM/

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Living with Google Glass, Day One: the reveal

DNP Living with Google Glass, Day One the reveal

In a loft atop Chelsea Market, Google is doing something special. Here, lucky Explorers will get their first taste of Project Glass. Yes, Google's latest X project (that we know about, at least) has finally made its way to the East Coast en masse. More importantly, it's also made its way to my face. A full Engadget review of the headset is most certainly on the way, but this is the sort of thing that will take some time to evaluate. You can quite quickly size up the next iteration of a great smartphone. Evaluating a wholly new product category to see how it fits into your life? That takes a little longer, dear readers.

I plan to spend a little while living with Glass in a variety of ways, some exciting and many less so, with the goal of getting comfortable with the thing -- or uncomfortable, if that's how it turns out. Given how many of you are excited to read about Google's new wearable, we wanted to let you come along for the ride. After all, isn't sharing an experience what Glass is really all about? Join me for my very first impressions after picking up my headset and some sample footage of the trip home.

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/u2bUDZk_glM/

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Thursday, April 25, 2013

Farrah Abraham "Desperate," Made Sex Tape After "Hitting Rock Bottom," Friend Says

Source: http://www.thehollywoodgossip.com/2013/04/farrah-abraham-desperate-made-sex-tape-after-hitting-rock-bottom/

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Verizon Galaxy S4 preorders begin tomorrow starting at $249.99

By Karolos Grohmann DORTMUND, Germany, April 24 (Reuters) - Real Madrid coach Jose Mourinho could not understand how his well-drilled side let Robert Lewandowski score four goals in Borussia Dortmund's 4-1 win on Wednesday but vowed that his team could still reach the Champions League final. The nine-times European champions have a huge task on their hands in Tuesday's home second leg after Mourinho acknowledged they had been outplayed in the semi-final first leg in Germany. "I saw a team that was better than the other one, mentally and physically. The better team won today. ...

Source: http://news.yahoo.com/verizon-galaxy-s4-preorders-begin-tomorrow-starting-249-155025326.html

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Splitsider Presents: A Place to Buy Awesome Comedy Where the Artists Actually Get Paid

The push towards DRM-free distribution has come in fits and spurts; Louis CK helped pioneer and popularize the model, but to date there still hasn't been a centralized hub where you can buy high-quality comedy, for a little bit of money, that the artist gets to keep. More »
    


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Judge dismisses three murder charges against Philly abortion doctor

(changes dateline, updates with Roura quotes) MUNICH, April 22 (Reuters) - Barcelona forward Lionel Messi, who has been struggling with a hamstring strain, is likely to face Bayern Munich in Tuesday's Champions League tie but his participation will be decided after a final training session, the Catalans said on Monday. "I wouldn't like to venture a definitive answer, but in these last few days, the injury has evolved well and we have a good sensation," interim coach Jordi Roura told a news conference. "But we will wait and see what happens in training. ...

Source: http://news.yahoo.com/pennsylvania-judge-dismisses-three-murder-charges-against-abortion-172027059.html

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Gwyneth Named "Most Hated"? C'mon, She's Not That Bad!

Haters gonna hate -- but how did Gwyneth Paltrow end up topping Lindsay Lohan and Chris Brown as Hollywood's most hated celebrity? The Iron Man 3 actress scored the top spot in Star magazine's annual poll of readers' least favorite stars. Granted, Gwyneth has made herself an easy target by trying to become a lifestyle guru to the little people. But we're not sure that eating lots of kale and being cluelessly privileged is the worst thing a celebrity can do.

Source: http://www.ivillage.com/gwyneth-paltrow-named-most-hated-hollywood-seriously-shes-not-bad/1-a-534146?dst=iv%3AiVillage%3Agwyneth-paltrow-named-most-hated-hollywood-seriously-shes-not-bad-534146

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Become A Successful Webmaster With These Practical Web Hosting ...

Author: Duncan Barua | Total views: 139 Comments: 0
Word Count: 671 Date:

Copyright (c) 2013 Design Web Limited

If you decide you want to sell handcrafted items online, you might not be sure how to set up your website to do so. For an e-commerce site, you will need to set up a shopping cart system. Keep in mind that not every web hosting company will give you this ability. There are other capabilities you want to check on before choosing a web host, so read on.

Switching to using a dedicated server can help meet your web hosting requirements. Dedicated servers are more secure. You can also get more disk space and bandwidth on a dedicated server. This ensures that visitors have no problems when visiting your site. Satisfied customers are more likely to continue using your services and are more likely to order more products.

When choosing a host for a site that needs more traffic, choose a host that has SEO features. A SEO feature will allow your site to be registered with multiple search engines. However, it doesn't hurt to register your website on your own time; this allows you to include detailed information and descriptions about the site and its intended purpose.

View the site of the web host you're considering. A poorly done site could mean a "red flag" for the hosting company. Such a website may indicate an inexperienced, incompetent or illegitimate provider. A well-designed, informative, and professional-looking site indicates a company's attentiveness to detail and their experience with web design.

Don't choose a host only because of their prices. You should consider all of the various features and options. A good price is not enough, so hold out for the option that best fits your situation. Your final choice should meet ALL of your needs, not just price.

Find out a web hosting company's history before choosing to use them. Make sure they've been around awhile and have a good background. You should make sure that the web hosting company has been in business for a minimum of a year. What would you do, after all, if your hosting company went out of business?

Before any final decision is made about a hosting site, be sure to learn about their safety and security features. You want to make sure that they provide a strict service that prevents hackers from accessing your site and information. A reputable host will back up their servers often.

When choosing a web host, make sure you find one that will quickly respond to your inquiries. Choose a host that communicates with its customers and answers any questions and notifies them of any important information. It is also important to have a hosting provider that can answer your questions should any problems arise.

Make sure you look at a web hosting company's site very carefully before you sign up with their hosting plan. You should find forums, contact information, and resources like support documentation. Figure out if the host will give you more resources and tutorials as soon as you become their client.

Find out if your web host offers refunds for downtime. You will only be given a small percentage of your monthly bill, likely to be a couple of pennies, and it won't compare to the losses in revenue you face. Choose a web host who has a good track record for uptime as opposed to offering refunds.

Ensure you are able to contact your host in the case of a problem. Web host that offer a variety of contact options are your best bet for getting good customer support. This will save you a lot of headaches, if something should happen.

If you're ever in doubt, look over the above tips to determine if the hosting company you're considering provides you the features that are sensible for your website. Know what you want to avoid over or under paying for hosting features.

Design Web Limited is a hosting company, offering unique products and services for individuals and businesses, with a focus on open source applications. Our goal is simply to be the best hosting company we can be. For more information on our web hosting products please visit Design Web. Click here for a free Drupal Hosting account.

AddThis Social Bookmark Button -- HTML code --

1: Article Marketing Strategy: Putting Together a "Class Schedule" For Your Article Topics

Businesses go to so much trouble when there is one sure-fire, simple, very inexpensive way to attract new clients to a business: Teach a free class. That is what article marketing is like. Your articles are just like free classes. You teach your target readers something helpful in your article. Your resource box then says, "If you enjoyed this article you can visit my website and apply what you have learned."

2: Why You Need To Build Multiple Streams of Income For Yourself

Being an entrepreneur and earning multiple streams of income is a dream that many have, but in reality it does take some initial hard work to achieve this. Earning multiple streams of income is the wave of the future, and here are some tips and advice for you when you are looking for ways in which to do this for yourself.

3: Understanding Online Business Success

Starting a home based business to earn income online takes a significant amount of time and energy upfront to get things going. Not seeing results immediately can be discouraging and cause people to give up too early. In this article, we look at the process of starting a home based business and working through the frustrations to be there when the sales come flowing in.

4: What is Cyber Marketing And Why It Is So Important For The Success Of Your Website

Cyber marketing has now become an indispensable segment of e-commerce as well as the internet and World Wide Web related topics. Cyber marketing simply refers to a technique of attracting potential customers by advertising your products or services through such means as websites, emails, and banners.

5: The Best Way To Optimise Your Website SEO For Google Panda

If you want your SEO to work you now need to concentrate on appeasing Google Panda, and to do this you need to know what Google Panda's spiders/bots will be looking for. Find out here how to search engine optimise your website for the latest Google Panda algorithm, and achieve the success you deserve.

Source: http://www.content4reprint.com/internet-marketing/become-a-successful-webmaster-with-these-practical-web-hosting-hints-and-tips.htm

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5 Big Brand PPC Ads with Critiques: What We Like, What We'd ...

What big brands are able to do with their enormous marketing budgets is inspiring ? though sometimes it mostly inspires jealousy. The typical small business can?t sponsor the Olympics or get an ad spot during the Super Bowl. You have to tinker around with more accessible campaigns that cost less but typically have smaller reach as well.

PPC is an example of an incredibly accessible marketing channel ? it?s being exploited by tiny one-man shops and huge multinational corporations alike. But how much better is a big-brand PPC ad than an SMB ad ? if at all? Is it like comparing the latest Pepsi commercial to what your local furniture store puts together?

Let?s look at five big-brand AdWords ads and see what they do well and what they could do better.

(More: Dear eBay, Your Ads Don't Work Because They Suck)

By the way, I fully admit to stealing the format for this post from Oli Gardner at Unbounce, who recently did something similar with big-brand landing pages. Thanks, Oli!

Big-Brand PPC Ad #1: LightingDirect.com

PPC Ad Example

A Google search for ?chandeliers? turned up these three ads in the coveted top-of-page ad spots. Let?s focus on the middle ad from LightingDirect.com (a Build.com network site), comparing it to its close competition.

What I Like:

  • Seller Ratings ? Both LightingDirect.com and LampsPlus are making use of the seller ratings extension available in AdWords. This helps them stand out a little more from the top-ranked ad. It?s working to the second ad?s advantage in particular because the company has over twice as many reviews as the third ad.
  • Lots of Benefits ? This ad manages to pack four different benefits (free shipping, easy returns, great selection, and friendly service) into a small amount of space. The other two ads only include two benefits in their message.

What I?d Change/Test:

  • Punctuation ? Putting punctuation at the end of the first line of descriptive text (a comma or period after ?Easy Returns?) would have made this ad easier to read, since top-ranked ads often find their two description lines expanded into a single long line. They could probably also increase CTR by including an exclamation point.
  • Call to Action ? There?s no explicit call to action in this ad. (The first ad makes the same mistake; the third ad has the ?Subscribe to newsletter? button to entice an action.) I might try losing one of those four benefits and turning one of the benefits into a CTA ? for example, ?Claim Your Free Shipping Offer? or ?Check Out Our Great Selection.?

Big-Brand PPC Ad #2: Audi

Brand Search PPC Ad

Unsurprisingly, Audi owns the top spot for a search on ?Audi.? (And yes, we think even small businesses should bid on branded terms.) So what are they doing with the prime real estate?

What I Like:

  • Sitelinks ? Sitelinks are an easy win: They make your ad bigger and give users many more places to click. In fact they increase CTR even when users aren't clicking the sitelines themselves, meaning you get a lift on the main headline link too.
  • Verbs ? Audi isn?t missing a call to action like LightingDirect was ? in fact, the main description line as well as every single sitelink includes a verb, enticing the searcher to take action.
  • Social Extensions ? Audi has an insane number of followers on Google+, so they?re right to show that number off. (According to Google: ?On average, search ads with annotations have a 5-10% uplift in click through rate and the AdWords Social Extension helps you show more of them.?)

What I?d Change/Test:

  • Headline ? Since this is the top result on a brand search, it probably has a super-duper high CTR, but nonetheless, I think the headline could be doing more work. All it really tells us is that this is the official site. Compare to this BMW ad that also tells us we can use the official site to build our own car.

Top Ranked PPC Ad

Big-Brand PPC Ad #3: Olay

Branded AdWords Ad

I know some of you dudes out there are thinking ?What the %^&$ is BB cream?? Basically, it?s like gussied up tinted moisturizer ? which is like a sheer foundation ? never mind. The point is, it?s makeup, and you can buy it. Let?s take a look at the Olay ad and the other competition in the yellow box.

What I Like:

  • Use of Symbols ? Did you know that using symbols, like the registered trademark symbol, can boost your ad performance? Test this now! They?re also using that powerful exclamation point.
  • Offers ? I like the specific offers in the sitelinks, especially ?Get a Free Skin Consultation,? which sounds like a great lead builder.

What I?d Change/Test:

  • Shorter Headline ? The headline is too long so it gets truncated. Instantly what? We don?t know.
  • Longer Description ? On the other hand, the description line is throwing away its extra characters, space that could have been used for a call to action (Maybelline?s CTA in the third ad is awesome) or to repeat the keyword (?BB Cream?) in the text again. Remember, when the search query appears in your ad, it appears in bold face, so your ad stands out more.

Big-Brand PPC Ad #4: ULINE

Bad PPC Ads

ULINE is one of the top PPC spenders in the business and industrial category, spending over $35 million a year on AdWords advertising. Are they making the most of that big PPC budget?

What I Like:

???? <crickets> ????

I don?t like much about this ad. Let?s get to what I don?t like.

What I?d Change/Test:

  • Better Keyword Matching ? It looks like they?re broad-matching on ?labels,? but they?re not using dynamic keyword insertion (DKI), so the word ?printing? doesn?t actually appear in the ad ? not a great intent match. The ad is all about designing and customizing labels, not printing them. They should be keeping a better watch over their search query report and building out more targeted ad groups.
  • More Benefits ? The only benefit here is ?Over 27,500 Products? ? which, some might argue, is actually a shortcoming. Who wants to search through nearly 30,000 products? Paradox of choice, anyone? Sounds like a waste of time. Compare this to the other two ads, which offer lots of information on price and specific details about label sizes and other information that would help the searcher make a decision.
  • Ad Extensions ? ULINE?s ad doesn?t make use of any extensions at all. Can we get a sitelink up in this piece?

Since ULINE?s ad is relatively weak compared to the #2 and #3 ads, they?re probably bidding higher and paying a lot more than their competitors per click.

Big-Brand PPC Ad #5: SelectQuote

PPC Ad Text Help

Here?s an ad that follows a lot of the best practices we?ve already mentioned ? clear call to action, using the search query in the text, sitelinks, etc. What are they doing that?s new?

What I Like:

  • The Local Connection ? SelectQuote has localized their ad to recognize my location. I?m in Colorado, so I might want to deal with a local agent.
  • Communication Extension ? Including a phone number means that your ad could lead to conversions even if they don?t click the ad. (That means it?s free, yay!)

What I?d Change/Test:

  • Numbers ? The top-ranked Metlife ad gets specific with numbers: ?Pay as little as $1/day for up to $500,000 coverage.? If I were SelectQuote?s PPC manager I?d test out concrete dollar amounts in my text too.
  • Appeal to Emotions ? People looking for life insurance might be driven by some strong emotions ? fear, compassion, concern for one?s loved ones, etc. An ad that speaks to those emotions could really do well here. I?d test something like ?Take Care of Your Family. Get a Free Quote Today.?

Do you steal from the big boys when it comes to writing ad text? Or do the little guys do it better?

Source: http://www.wordstream.com/blog/ws/2013/04/24/big-brand-ppc-ads

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'Fairy' insect is mind-blowingly tiny

John T. Huber

Tinkerbella nana, a new species of fairyfly from Costa Rica, is named after the fairy in "Peter Pan.".

By Stephanie Pappas
LiveScience

A new species of tiny fly named after the fairy in "Peter Pan" is mind-blowingly minuscule, with delicate wings trimmed in fringe.

Tinkerbella nana is a newly discovered species of fairyfly from Costa Rica. Fairyflies are a type of chalcid wasp, and almost all are parasites, living on the eggs and larvae of other insects. It's a gruesome way to live, but it makes fairyflies useful for farmers, who sometimes import them to control nasty pests.

John T. Huber

Tinkerbella nana is only about 250 nanometers long.

Many fairyflies are extraordinarily tiny, including Kikiki huna, a Hawaiian species that grows to be only 0.005 inches (0.13 millimeters) long ? about the diameter of the tip of a fine drawing pen. This makes them tough to find, but researchers led by John Huber of Natural Resources Canada conducted their search by seeking out insect eggs in leaf litter, soil and on plants in the Costa Rican province of Alajeula.

There, they found specimens of T. nana, none of which were more than 250 micrometers in length. One micrometer is a thousandth of a millimeter.

Under the microscope, these teeny-tiny insects reveal fine detail, particularly their long, skinny wings, which terminate in hairlike fringe. This wing shape may help ultra-small insects reduce turbulence and drag when they fly, a feat that requires beating their wings hundreds of times per second.

Researchers don't know how small insects can get, Huber said.

"If we have not already found them, we must surely be close to discovering the smallest insects," he said in a statement. The researchers published their discovery Wednesday in the Journal of Hymenoptera Research.

Follow Stephanie Pappas on Twitter?and Google+. Follow us @livescience, Facebook?and Google+. Original article on LiveScience.com.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2b206705/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A40C240C178972790Efairy0Einsect0Eis0Emind0Eblowingly0Etiny0Dlite/story01.htm

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Reliance Communications Partners With Twitter To Offer Free ...

For those in the United States and other locations that are lucky enough to be able to purchase huge data packages for their smartphones, thinking about deciding to ?tweet or not to tweet? based on the cost that it could incur is a foreign concept, pun intended. For cell customers in India, it?s a very real situation, and Reliance Communications has partnered with Twitter to bring free, unlimited access to the social network to its prepaid GSM subscribers.

This is yet another example of how important Twitter has become in our daily lives and how integral the communication platform is to locations all over the world. The service will be bundled with live cricket match updates, the most popular sport in the country.

A customized version of the Twitter app has been created, reminding customers that they?re getting free access thanks to Reliance Mobile. If someone taps a link to an outside site, they will be reminded that doing so might incur extra charges.

Reliance is the first operator to partner with Twitter in India, and its Chief Revenue Officer of Wireless, Nilanjan Mukherjee, had this to share:

We are delighted to be the first operator to partner with Twitter in India on Twitter Access and offer the first of its kind unlimited Twitter access on our superior network. Our partnership with Twitter in India further strengthens our offering on the social media platform and is in line with our continuous efforts to offer innovative products with incredible affordability for our customers.

Since prepaid cell phones are prominent in countries like India, signing deals like this makes the services more attractive. Back to how important cricket is to India?s culture, though. Mukherjee feels like this announcement could cause a ?significant shift? of cricket fans to move over to Reliance.

That?s knowing your customers.

[Photo credit: Flickr]


Created in 2006, Twitter is a global real-time communications platform with 400 million monthly visitors to twitter.com, more than 200 million monthly active users around the world. We see a billion tweets every 2.5 days on every conceivable topic. World leaders, major athletes, star performers, news organizations and entertainment outlets are among the millions of active Twitter accounts through which users can truly get the pulse of the planet.

? Learn more

Reliance Communications is an Indian telecommunications service provider.

? Learn more

Source: http://techcrunch.com/2013/04/23/reliance-communications-partners-with-twitter-to-offer-free-unlimited-access-to-the-service-in-india/

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Wednesday, April 24, 2013

What drives activity on Pinterest?

Apr. 23, 2013 ? Researchers at Georgia Tech and the University of Minnesota have released a new study that uses statistical data to help understand the motivations behind Pinterest activity, the roles gender plays among users and the factors that distinguish Pinterest from other popular social networking sites.

Led by Assistant Professor Eric Gilbert of Georgia Tech's School of Interactive Computing, working in collaboration with Professor Loren Terveen from the University of Minnesota's College of Science and Engineering, the study reveals findings that could have implications for both academia and industry:

1. Female users have more re-pins, regardless of geographical location

2. Men typically have more followers on Pinterest than women

3. Four verbs set Pinterest apart from Twitter: "use," "look," "want" and "need"

"Those four verbs uniquely describe Pinterest and are particularly interesting," said Gilbert, who runs the Comp.Social Lab at Georgia Tech. "Words encapsulate the intent of people, revealing the motivations behind their actions. You can use the word 'this' after all of these verbs, reflecting the 'things' at the core of Pinterest. Many press articles have focused on Pinterest's commercial potential, and here we see verbs illustrating that consumption truly lies at the heart of the site."

Pinterest, which reached 10 million users faster than any other social network, revolves around the metaphor of a pin board: users "pin" photos they find on the web and organize them into topical collections. Pinterest users can follow one another and also re-pin, like and comment on other pins. After examining more than 200,000 pins, Gilbert and his team were able to compile the first statistical overview of the site.

"We wanted to take a closer look at Pinterest because of its differences compared to other social media, including its focus on pictures and products and the large proportion of women users," said Terveen, a co-author of the study. "These findings are an important early snapshot of Pinterest that help us begin to understand people's activity on this site."

Understanding the motivations behind activity on Pinterest is key, not only for researchers but also for business wishing to utilize the site for marketing purposes. A recent market survey showed that a higher proportion of Pinterest users click through to e-commerce sites -- and when they go there, they spend significantly more money than people who come from sites like Facebook or Twitter.

"There are several social networking sites that marketers and advertisers can take advantage of these days," said Gilbert. "After conducting this research, if I had to choose where to put my money and marketing, Pinterest would probably be my first choice."

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Story Source:

The above story is reprinted from materials provided by Georgia Institute of Technology.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Eric Gilbert, Saeideh Bakhshi, Shuo Chang, Loren Terveen. ?I Need to Try This!?: A Statistical Overview of Pinterest. Sociology of Education, 2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/qBhD0J55Poc/130423135722.htm

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ALS trial suggests novel therapy is safe

Apr. 23, 2013 ? An investigational treatment for an inherited form of Lou Gehrig's disease has passed an early phase clinical trial for safety, researchers at Washington University School of Medicine in St. Louis and Massachusetts General Hospital report.

The researchers have shown that the therapy produced no serious side effects in patients with the disease, also known as amyotrophic lateral sclerosis (ALS). The phase 1 trial's results, available online in Lancet Neurology, also demonstrate that the drug was successfully introduced into the central nervous system.

The treatment uses a technique that shuts off the mutated gene that causes the disease. This approach had never been tested against a condition that damages nerve cells in the brain and spinal cord.

"These results let us move forward in the development of this treatment and also suggest that it's time to think about applying this same approach to other mutated genes that cause central nervous system disorders," says lead author Timothy Miller, MD, PhD, assistant professor of neurology at Washington University. "These could include some forms of Alzheimer's disease, Parkinson's disease, Huntington's disease and other conditions."

ALS destroys nerves that control muscles, gradually leading to paralysis and death. For treatment of the disease, the sole FDA-approved medication, Riluzole, has only a marginal effect.

Most cases of ALS are sporadic, but about 10 percent are linked to inherited mutations. Scientists have identified changes in 10 genes that can cause ALS and are still looking for others.

The study focused on a form of ALS caused by mutations in a gene called SOD1, which account for 2 percent of all ALS cases. Researchers have found more than 100 mutations in the SOD1 gene that cause ALS.

"At the molecular level, these mutations affect the properties of the SOD1 protein in a variety of ways, but they all lead to ALS," says Miller, who is director of the Christopher Wells Hobler Lab for ALS Research at the Hope Center for Neurological Disorders at Washington University.

Rather than try to understand how each mutation causes ALS, Miller and his colleagues focused on blocking production of the SOD1 protein using a technique called antisense therapy.

To make a protein, cells have to copy the protein-building instructions from the gene. Antisense therapy blocks the cell from using these copies, allowing researchers to selectively silence individual genes.

"Antisense therapy has been considered and tested for a variety of disorders over the past several decades," Miller says. "For example, the FDA recently approved an antisense therapy called Kynamro for familial hypercholesterolemia, an inherited condition that increases cholesterol levels in the blood."

Miller and colleagues at the University of California-San Diego devised an antisense drug for SOD1 and successfully tested it in an animal model of the disease.

Merit Cudkowicz, MD, chief of neurology at Massachusetts General Hospital, was co-PI of the phase I clinical safety trial described in the new paper. Clinicians at Barnes-Jewish Hospital, Massachusetts General Hospital, Johns Hopkins Hospital and the Methodist Neurological Institute in Houston gave antisense therapy or a placebo to 21 patients with SOD1-related ALS. Treatment consisted of spinal infusions that lasted 11 hours.

The scientists found no significant difference between side effects in the control and treatment groups. Headache and back pain, both of which are often associated with spinal infusion, were among the most common side effects.

Immediately after the injections, the researchers took spinal fluid samples. This let them confirm the antisense drug was circulating in the spinal fluid of patients who received the treatment.

To treat SOD1-related ALS in the upcoming phase II trial, researchers will need to increase the dosage of the antisense drug. As the dose rises, they will watch to ensure that the therapy does not cause harmful inflammation or other side effects as it lowers SOD1 protein levels.

"All the information that we have so far suggests lowering SOD1 will be safe," Miller says. "In fact, completely disabling SOD1 in mice seems to have little to no effect. We think it will be OK in patients, but we won't know for sure until we've conducted further trials."

The therapy may one day be helpful in the more common, noninherited forms of ALS, some of which may be linked to problems with the SOD1 protein.

"Before we can consider using this same therapy for sporadic ALS, we need more evidence that SOD1 is a major contributor to these forms of the disorder," Miller says.

The trial was conducted with support from ISIS Pharmaceuticals, which co-owns a patent on the SOD1 antisense drug.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Washington University School of Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Timothy M Miller, Alan Pestronk, William David, Jeffrey Rothstein, Ericka Simpson, Stanley H Appel, Patricia L Andres, Katy Mahoney, Peggy Allred, Katie Alexander, Lyle W Ostrow, David Schoenfeld, Eric A Macklin, Daniel A Norris, Georgios Manousakis, Matthew Crisp, Richard Smith, C Frank Bennett, Kathie M Bishop, Merit E Cudkowicz. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study. The Lancet Neurology, 2013; 12 (5): 435 DOI: 10.1016/S1474-4422(13)70061-9

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Yau30vTMth4/130423172722.htm

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